Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250969 | 0.90 | TAS2R14 (0.47) | KIF11GAAMEN1KMT2AMAPT | |
| SCHEMBL11095537 | 0.87 | KIF11 (0.59) | KIF11MEN1KMT2AKDM4E | |
| SCHEMBL11255374 | 0.86 | KIF11 (0.43) | KIF11MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11580545 | 0.84 | ALDH1A1 (0.55) | KIF11MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11579884 | 0.84 | KIF11 (0.44) | KIF11MEN1KMT2AMAPTKDM4E | |
| SCHEMBL11254202 | 0.82 | ALDH1A1 (0.46) | MEN1KMT2AMAPTHTTRAB9A | |
| SCHEMBL11255956 | 0.82 | MEN1 (0.42) | GAASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL11579511 | 0.82 | MEN1 (0.56) | MEN1KMT2AHTTRAB9APOLB | |
| SCHEMBL23752446 | 0.82 | ALDH1A1 (0.57) | GAAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11877833 | 0.82 | KIF11 (0.43) | KIF11GAASLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446152-A | SUBSTITUTED PHENYLAMIDINOUREA | WILLIAM H. RORER, INC. (US) | 1984-05-01 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4115564-A | Treatment of diarrhea with amidinoureas | WILLIAM H. RORER, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |