Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levothyroxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 9/20 | 0.73 |
| ▸ | THRA known ✓ | P10827 | 6/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | PPARG | P37231 | 4/20 | 0.73 |
| ▸ | TTR | P02766 | 2/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.73 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thyroxine SCHEMBL4732818 | 0.89 | THRB (0.88) | THRBTHRAMEN1KMT2ALMNA | |
| Levothyroxine SCHEMBL17758147 | 0.86 | THRB (0.82) | THRBTHRAMEN1KMT2ALMNA | |
| Thyroxine SCHEMBL11131863 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Levothyroxine SCHEMBL4997979 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Dextrothyroxine SCHEMBL30885760 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Thyroxine SCHEMBL26147 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Thyroxine SCHEMBL7944262 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Levothyroxine SCHEMBL23098 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Thyroxine SCHEMBL4575383 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA | |
| Dextrothyroxine SCHEMBL61194 | 0.86 | THRB (1.00) | THRBTHRAMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486534-A | REVERSIBLE COMPLEXING | BOEHRINGER MANNHEIM GMBH (DE) | 1984-12-04 | — | — | US | disclosed |