Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091478 | 0.78 | NPC1 (0.46) | POLBTDP1HSD17B10HPGDHTT | |
| SCHEMBL11074467 | 0.76 | LMNA (0.46) | POLBHSD17B10HPGDALDH1A1CYP1A2 | |
| SCHEMBL11099776 | 0.74 | HSD17B10 (0.51) | TDP1HSD17B10HPGDHTTALDH1A1 | |
| SCHEMBL11823942 | 0.74 | HSD17B10 (0.38) | POLBTDP1HSD17B10HPGDHTT | |
| SCHEMBL11826046 | 0.74 | HSD17B10 (0.38) | POLBHSD17B10HPGDHTTALDH1A1 | |
| SCHEMBL11828529 | 0.73 | TDP1 (0.41) | POLBTDP1HSD17B10HPGDHTT | |
| SCHEMBL11097777 | 0.73 | HSD17B10 (0.37) | HSD17B10ALDH1A1CYP1A2CYP2C19RAB9A | |
| SCHEMBL11822542 | 0.72 | HSD17B10 (0.38) | HSD17B10HPGDALDH1A1CYP2C9TSHR | |
| SCHEMBL11259430 | 0.72 | RXRA (0.38) | POLBHSD17B10HPGDHTTALDH1A1 | |
| SCHEMBL11822888 | 0.72 | HSD17B10 (0.46) | HSD17B10HPGDHTTALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |