Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384417 | 0.88 | HSD17B10 (0.66) | HSD17B10CASP1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL7421932 | 0.81 | CASP1 (0.53) | HSD17B10CASP1ALDH1A1CYP2C9L3MBTL1 | |
| SCHEMBL7424415 | 0.80 | CASP1 (0.50) | HSD17B10CASP1L3MBTL1 | |
| SCHEMBL11830247 | 0.79 | CASP1 (0.54) | HSD17B10CASP1ALDH1A1CYP2C9TSHR | |
| SCHEMBL11091478 | 0.78 | NPC1 (0.46) | HSD17B10CASP1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5703639 | 0.78 | PDE4B (0.50) | HSD17B10CASP1 | |
| SCHEMBL11830796 | 0.78 | MAPT (0.38) | HSD17B10CASP1ALDH1A1CYP2C9TSHR | |
| SCHEMBL11099780 | 0.78 | HDAC1 (0.43) | HSD17B10ALDH1A1TSHRHPGDCYP1A2 | |
| SCHEMBL7375552 | 0.76 | HSD17B10 (0.64) | HSD17B10CASP1ALDH1A1TSHRCYP1A2 | |
| SCHEMBL11074467 | 0.76 | LMNA (0.46) | HSD17B10CASP1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |