Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353916 | 0.91 | AKR1B1 (0.37) | AKR1B1KMT2AFFAR1GPR17KDM4E | |
| SCHEMBL11818697 | 0.84 | AKR1B1 (0.32) | AKR1B1KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL11097563 | 0.83 | FFAR1 (0.38) | AKR1B1KMT2AFFAR1TSHRALDH1A1 | |
| SCHEMBL11818684 | 0.80 | NLRP3 (0.43) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL11818689 | 0.79 | EPHX2 (0.36) | KMT2AKDM4EMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8180989 | 0.77 | KIF11 (0.40) | KMT2AKDM4ETSHRMEN1FEN1 | |
| SCHEMBL11075302 | 0.76 | CYP2C19 (0.40) | FFAR1TSHRALDH1A1ESR1CYP3A4 | |
| SCHEMBL11066784 | 0.75 | MIF (0.47) | KMT2AFFAR1KDM4ETSHRMEN1 | |
| SCHEMBL6139367 | 0.75 | TSHR (0.38) | FFAR1TSHRALDH1A1ESR1CYP3A4 | |
| SCHEMBL11823090 | 0.75 | MEN1 (0.31) | AKR1B1KMT2AKDM4ETSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |