Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.51 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450078 | 0.90 | KDM4E (0.71) | KDM4EHSD17B3CASP7GAAHSD17B10 | |
| Acetic Acid SCHEMBL15653002 | 0.85 | KDM4E (0.66) | KDM4EHSD17B3VKORC1CYP2C9HSD17B10 | |
| SCHEMBL28194448 | 0.80 | KDM4E (0.51) | KDM4EVKORC1CYP2C9NQO1GAA | |
| SCHEMBL15842710 | 0.80 | KDM4E (0.54) | KDM4EVKORC1CYP2C9NQO1CRHBP | |
| SCHEMBL15980779 | 0.80 | KDM4E (0.59) | KDM4EVKORC1CYP2C9NQO1CRHBP | |
| SCHEMBL5459905 | 0.79 | KDM4E (1.00) | KDM4EVKORC1CYP2C9NQO1CA12 | |
| SCHEMBL29695571 | 0.79 | KDM4E (1.00) | KDM4EVKORC1CYP2C9NQO1CA12 | |
| SCHEMBL30153359 | 0.79 | KDM4E (0.73) | KDM4EVKORC1CYP2C9NQO1HSD17B10 | |
| SCHEMBL5532851 | 0.79 | KDM4E (0.73) | KDM4EVKORC1CYP2C9NQO1HSD17B10 | |
| Dibenzofuran SCHEMBL11326579 | 0.78 | SMN1; SMN2 (0.52) | KDM4EVKORC1CYP2C9CASP7GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427680-A | ANTHISTAMINES | BOEHRINGER MANNHEIM GMBH (DE) | 1984-01-24 | — | — | US | disclosed |
| US-4330549-A | Coumarins connected via an oxyalkyl group with a piperidine ring having anti-allergic action | BOEHRINGER MANNHEIM GMBH (DE) | 1982-05-18 | — | — | US | disclosed |