Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.50 |
| ▸ | NQO1 | P15559 | 3/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MGAM | O43451 | 2/20 | 0.47 |
| ▸ | SI | P14410 | 2/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15842710 | 0.86 | KDM4E (0.54) | KDM4ECYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL5730839 | 0.85 | CYP2C9 (0.56) | CYP2C9NQO1CRHBPCASP7CASP6 | |
| SCHEMBL2450078 | 0.81 | KDM4E (0.71) | KDM4ECASP7GAAHSD17B10ALDH1A1 | |
| Isopropyl Alcohol SCHEMBL11096119 | 0.80 | KDM4E (0.66) | KDM4ECYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL14078661 | 0.77 | NQO1 (0.73) | CYP2C9NQO1CRHBPCASP7CASP6 | |
| SCHEMBL10238246 | 0.77 | CA2 (0.42) | KDM4ECYP2C9NQO1CRHBPCASP7 | |
| SCHEMBL94134 | 0.74 | GAA (0.69) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL5459905 | 0.74 | KDM4E (1.00) | KDM4ECYP2C9NQO1VKORC1ALDH1A1 | |
| SCHEMBL1992305 | 0.74 | KDM4E (0.62) | KDM4ECYP2C9NQO1CASP7GAA | |
| SCHEMBL29695571 | 0.74 | KDM4E (1.00) | KDM4ECYP2C9NQO1VKORC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243321-A1 | BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243286-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | COFERON, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243322-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | COFERON, INC. (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243322-A1 | BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME | BRDT, BRD2, BRD4 | KDM4E 1492/4885CYP2C9 4808/4885NQO1 2908/4885 |
| US-20140243286-A1 | BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME | BRDT, BRD4, BRD1 | KDM4E 3073/4885CYP2C9 4877/4885NQO1 3275/4885 |
| US-20140243321-A1 | BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS, AND METHODS OF USING SAME | BRDT, BRD4, BRD1 | KDM4E 3162/4885CYP2C9 4863/4885NQO1 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.