Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 8/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27585285 | 0.81 | KDM4E (0.39) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL2484772 | 0.76 | CYP19A1 (0.42) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL1614409 | 0.72 | HTT (0.40) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL28673403 | 0.70 | AR (0.34) | ALDH1A1KDM4ECCR2 | |
| SCHEMBL6887346 | 0.70 | CYP19A1 (0.43) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL24919786 | 0.69 | CYP19A1 (0.45) | ALDH1A1CCR2CYP19A1NAAACCR1 | |
| SCHEMBL8676129 | 0.69 | CYP19A1 (0.45) | ALDH1A1CCR2CYP19A1NAAACCR1 | |
| SCHEMBL5857915 | 0.69 | CYP19A1 (0.45) | ALDH1A1CCR2CYP19A1NAAACCR1 | |
| SCHEMBL5754395 | 0.69 | CCR2 (0.42) | ALDH1A1KDM4EMEN1MAPTPKM | |
| SCHEMBL17187540 | 0.69 | CYP19A1 (0.45) | ALDH1A1CCR2CYP19A1NAAACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031058-B1 | SULFONYL UREAS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-04-04 | — | — | EP | disclosed |
| US-4379785-A | Heterocyclic substituted sulfonyl ureas, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-12 | — | — | US | disclosed |
| EP-0031058-A1 | Sulfonyl ureas, processes for their preparation and pharmaceutical compositions containing these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-01 | — | — | EP | disclosed |