Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11102151 | 0.87 | CYP1A2 (0.45) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL15658611 | 0.84 | LMNA (0.49) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL3308807 | 0.84 | LMNA (0.66) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL11099819 | 0.83 | SMN1; SMN2 (0.49) | LMNACYP1A2AGTR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6482750 | 0.81 | CYP1A2 (0.73) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL6482753 | 0.81 | CYP1A2 (0.73) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL22114346 | 0.80 | SMN1; SMN2 (0.52) | LMNACYP1A2AGTR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL772495 | 0.80 | ALOX15 (0.56) | LMNACYP1A2AGTR1SMN1; SMN2KDM4E | |
| SCHEMBL11099556 | 0.76 | ALDH1A1 (0.45) | LMNACYP1A2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3157708 | 0.76 | SMN1; SMN2 (0.55) | LMNACYP1A2SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054132-B1 | PYRIMIDONES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-10-10 | — | — | EP | disclosed |
| US-4379788-A | HYPOTENSIVES, ANTIARRHYTHMIA, B-BLOCKERS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-04-12 | — | — | US | disclosed |
| EP-0054132-A1 | Pyrimidones, their preparation and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1982-06-23 | — | — | EP | disclosed |