Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384228 | 0.87 | PLAU (0.49) | PLAUADORA2ARAB9AL3MBTL1TDP1 | |
| SCHEMBL11181834 | 0.87 | HRH2 (0.40) | PLAUSCN5ASCN2AADORA2AMAPT | |
| SCHEMBL11096144 | 0.86 | HTR1A (0.39) | PLAUSCN5ASCN2AADORA2ARAB9A | |
| Hydrochloric Acid SCHEMBL11191536 | 0.86 | HRH2 (0.40) | PLAUSCN5ASCN2AADORA2AMAPT | |
| SCHEMBL11093891 | 0.84 | PLAU (0.35) | PLAUADORA2ARAB9AL3MBTL1MAPT | |
| SCHEMBL11093888 | 0.84 | PLAU (0.35) | PLAUADORA2ARAB9AL3MBTL1MAPT | |
| SCHEMBL11158296 | 0.84 | PLAU (0.43) | PLAUADORA2ARAB9AL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL11090431 | 0.83 | PLAU (0.35) | PLAUADORA2ARAB9AL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL11090433 | 0.83 | PLAU (0.35) | PLAUADORA2ARAB9AL3MBTL1MAPT | |
| SCHEMBL11385886 | 0.82 | HRH2 (0.33) | PLAUADORA2ARAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4426526-A | HISTAMINE ANTAGONISTS, ANTIINFLAMMATORY, ANTISECRETORY | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-01-17 | — | — | US | disclosed |
| US-4264608-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-04-28 | — | — | US | disclosed |
| US-4215126-A | HISTAMINE H2 BLOCKING | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-29 | — | — | US | disclosed |
| US-4156727-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-29 | — | — | US | disclosed |
| US-4154838-A | ANTIHISTAMINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-05-15 | — | — | US | disclosed |