Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8384228 | 0.88 | PLAU (0.49) | PLAUALDH1A1MAPTHTTRAB9A | |
| SCHEMBL11163585 | 0.85 | NOS3 (0.31) | PLAUNOS3NOS1NOS2LMNA | |
| SCHEMBL11096324 | 0.84 | PLAU (0.42) | PLAUALDH1A1MAPTHTTRAB9A | |
| Hydrochloric Acid SCHEMBL11217448 | 0.82 | PLAU (0.41) | PLAUALDH1A1MAPTHTTRAB9A | |
| Hydrochloric Acid SCHEMBL11090433 | 0.81 | PLAU (0.35) | PLAUMAPTRAB9AL3MBTL1ADORA2A | |
| Hydrochloric Acid SCHEMBL11090431 | 0.81 | PLAU (0.35) | PLAUMAPTRAB9AL3MBTL1ADORA2A | |
| SCHEMBL11181834 | 0.81 | HRH2 (0.40) | PLAUMAPTADORA2ALMNA | |
| Hydrochloric Acid SCHEMBL11191536 | 0.80 | HRH2 (0.40) | PLAUMAPTADORA2ALMNA | |
| SCHEMBL11096144 | 0.80 | HTR1A (0.39) | PLAURAB9AL3MBTL1ADORA2ATSHR | |
| SCHEMBL11091903 | 0.79 | HTR1A (0.39) | PLAUALDH1A1RAB9AL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4372963-A | HISTAMINE ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-02-08 | — | — | US | disclosed |
| US-4285952-A | Pyridyl, thiazolyl and isothiazolyl alkyl bisamidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-08-25 | — | — | US | disclosed |
| US-4212875-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1980-07-15 | — | — | US | disclosed |