Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | ARG1 | P05089 | 1/20 | 0.45 |
| ▸ | ARG2 | P78540 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036161 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL4037021 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL4036159 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL4037015 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL4039195 | 0.81 | DRD2 (0.55) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL11126802 | 0.81 | MEN1 (0.55) | SIGMAR1ALDH1A1KMT2AMEN1KCNH2 | |
| SCHEMBL5351903 | 0.80 | CHRM2 (0.53) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL4521492 | 0.80 | CHRM2 (0.53) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL5301358 | 0.79 | SMN1; SMN2 (0.53) | DRD2DRD4DRD3ARG1ARG2 | |
| SCHEMBL11266772 | 0.77 | LTA4H (0.48) | SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031219-B1 | ANILINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1984-03-07 | — | — | EP | disclosed |
| US-4350691-A | ANTIEMETICS | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| EP-0031219-A1 | Aniline derivatives | BEECHAM GROUP PLC (GB) | 1981-07-01 | — | — | EP | disclosed |