Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.49 |
| ▸ | ARG1 | P05089 | 1/20 | 0.45 |
| ▸ | ARG2 | P78540 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036161 | 0.82 | DRD2 (0.55) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL4036159 | 0.82 | DRD2 (0.55) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL4039195 | 0.82 | DRD2 (0.55) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL4034860 | 0.82 | KMT2A (0.51) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL4037015 | 0.82 | DRD2 (0.55) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL4037021 | 0.82 | DRD2 (0.55) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL27676903 | 0.82 | DRD2 (0.51) | POLBDRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL11097099 | 0.79 | DRD2 (0.52) | SMN1; SMN2POLBDRD2DRD4DRD3 | |
| SCHEMBL11094859 | 0.77 | ARG1 (0.54) | SMN1; SMN2DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL11094861 | 0.77 | ARG1 (0.54) | SMN1; SMN2DRD2DRD4DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453511-A1 | TROPANE DERIVATIVES HAVING DOPAMINE REUPTAKE INHIBITOR ACTIVITY FOR THE TREATMENT OF ISCHEMIC DISEASES | NEUROSEARCH A/S (DK) | 2004-09-08 | — | — | EP | claimed |
| WO-2003045388-A1 | TROPANE DERIVATIVES HAVING DOPAMINE REUPTAKE INHIBITOR ACTIVITY FOR THE TREATMENT OF ISCHEMIC DISEASES | NEUROSEARCH A/S (DK) | 2003-06-05 | — | — | WO | claimed |
| WO-2007028770-A1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS FOR NEUROPROTECTION IN PATIENTS SUFFERING FROM AN ADVANCED STAGE OF A MENTAL DISEASE | NEUROSEARCH A/S (DK) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007028769-A1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR NEUROPROTECTION | NEUROSEARCH A/S (DK) | 2007-03-15 | — | — | WO | disclosed |
| EP-1755602-A1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (A BETA 40 AND A BETA 42) GENERATION | NEUROSEARCH A/S (DK) | 2007-02-28 | — | — | EP | disclosed |
| EP-1429811-A4 | THEURAPEUTIC TROPANE COMPOUNDS | HARVARD COLLEGE (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005117874-A1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION | NEUROSEARCH A/S (DK) | 2005-12-15 | — | — | WO | disclosed |
| EP-1429811-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003015830-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-02-27 | — | — | WO | disclosed |
| US-6395748-B2 | Use treating Alzheimer's disease; monoamine reuptake inhibitor tropanes such as tesofensine (2-methoxymethyl-3-(3,4-dichlorophenyl)-tropane) | NEUROSEARCH A/S (DK) | 2002-05-28 | — | — | US | disclosed |
| US-6288079-B1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS; NERVOUS SYSTEM, PSYCHOLOGICAL, EATING, SLEEP, AND BRAIN DISORDERS; ALZHEIMER*S AND PARKINSON*S DISEASE; TESOFENSINE (2-ethoxymethyl-3-(3,4-dichlorophenyl)-tropane) | NEUROSEARCH A/S (DK) | 2001-09-11 | — | — | US | disclosed |
| EP-0885220-A1 | TROPANE-DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997030997-A1 | TROPANE-DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-08-28 | — | — | WO | disclosed |