Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbinil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 known ✓ | P15121 | 3/20 | 0.78 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.78 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbinil SCHEMBL48877 | 0.88 | AKR1B10 (1.00) | AKR1B1AKR1B10AKR1A1MAPT | |
| Sorbinil SCHEMBL17223865 | 0.88 | AKR1B10 (1.00) | AKR1B1AKR1B10AKR1A1MAPT | |
| Sorbinil SCHEMBL2108408 | 0.88 | AKR1B10 (1.00) | AKR1B1AKR1B10AKR1A1MAPT | |
| Sorbinil SCHEMBL29599732 | 0.88 | AKR1B10 (1.00) | AKR1B1AKR1B10AKR1A1MAPT | |
| Sorbinil SCHEMBL9790028 | 0.88 | AKR1B10 (1.00) | AKR1B1AKR1B10AKR1A1MAPT | |
| Sorbinil SCHEMBL11088391 | 0.84 | AKR1B10 (0.78) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL7867894 | 0.82 | AKR1B10 (0.80) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL12620675 | 0.82 | AKR1B10 (0.80) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL11342164 | 0.77 | AKR1B1 (0.71) | AKR1B1AKR1B10AKR1A1MAPT | |
| SCHEMBL11343783 | 0.76 | AKR1B1 (0.65) | AKR1B1AKR1B10AKR1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0124327-A2 | Hydantoin derivatives | PFIZER INC. (US) | 1984-11-07 | — | — | EP | claimed |
| EP-0124327-A2 | Hydantoin derivatives | PFIZER INC. (US) | 1984-11-07 | — | — | EP | disclosed |
| US-4474967-A | ANTIDIABETIC AGENTS, ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1984-10-02 | — | — | US | disclosed |