Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbinil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 known ✓ | P15121 | 1/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | AKR1A1 | P14550 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbinil SCHEMBL17223865 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL9790028 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL2108408 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL48877 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL12620675 | 0.89 | AKR1B10 (0.80) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7867894 | 0.89 | AKR1B10 (0.80) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL11088391 | 0.88 | AKR1B10 (0.78) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL11097273 | 0.88 | AKR1B1 (0.78) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL3439473 | 0.86 | AKR1B1 (0.76) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL9824214 | 0.86 | AKR1B1 (0.76) | AKR1B10MAPTAKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111065392-B | Compositions and methods for treating galactosylation | 应用治疗公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-111671906-B | Application of AKR1B inhibitor in preparation of medicine for treating lung cancer | 上海交通大学医学院 | 2022-06-10 | — | — | CN | disclosed |