Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sorbinil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 known ✓ | P15121 | 1/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | AKR1A1 | P14550 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sorbinil SCHEMBL17223865 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL9790028 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL29599732 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL2108408 | 1.00 | AKR1B10 (1.00) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL12620675 | 0.89 | AKR1B10 (0.80) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL7867894 | 0.89 | AKR1B10 (0.80) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL11088391 | 0.88 | AKR1B10 (0.78) | AKR1B10MAPTAKR1A1AKR1B1 | |
| Sorbinil SCHEMBL11097273 | 0.88 | AKR1B1 (0.78) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL3439473 | 0.86 | AKR1B1 (0.76) | AKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL9824214 | 0.86 | AKR1B1 (0.76) | AKR1B10MAPTAKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2256 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240374693-A1 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIVERSITY OF ROCHESTER | 2024-11-14 | — | — | US | claimed |
| US-12083168-B2 | Treatment and detection of inherited neuropathies and associated disorders | UNIVERSITY OF MIAMI (US) | 2024-09-10 | — | — | US | claimed |
| WO-2024064147-A1 | TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2024-03-28 | — | — | WO | claimed |
| WO-2024053761-A1 | COMPOSITION FOR PROMOTING MYOBLAST PROLIFERATION AND DIFFERENTIATION CONTAINING ALDOSE REDUCTASE INHIBITOR | 애니머스큐어 주식회사 | 2024-03-14 | — | — | WO | claimed |
| US-20240003908-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2024-01-04 | — | — | US | claimed |
| US-20230293642-A9 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIVERSITY OF ROCHESTER | 2023-09-21 | — | — | US | claimed |
| EP-4244243-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | Mayo Foundation for Medical Education and Research (US) | 2023-09-20 | — | — | EP | claimed |
| US-20220249624-A1 | TREATMENT AND DETECTION OF INHERITED NEUROPATHIES AND ASSOCIATED DISORDERS | UNIV MIAMI (US) | 2022-08-11 | — | — | US | claimed |
| CN-111671906-B | Application of AKR1B inhibitor in preparation of medicine for treating lung cancer | 上海交通大学医学院 | 2022-06-10 | — | — | CN | claimed |
| WO-2022103815-A1 | POLYOL BIOMARKERS FOR CONGENITAL DISORDERS OF GLYCOSYLATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2022-05-19 | — | — | WO | claimed |
| EP-0251680-A2 | Controlled release bioerodible drug delivery system | IOLAB, INC (US) | 1988-01-07 | — | — | EP | claimed |
| US-4704461-A | Processes and intermediates for sorbinil | PFIZER INC. (US) | 1987-11-03 | — | — | US | claimed |
| EP-0224352-A1 | Ocular treatment | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-06-03 | — | — | EP | claimed |
| EP-0109231-B1 | SORBINIL BY OPTICAL RESOLUTION WITH AMINOPINANE DERIVATIVES | PFIZER INC. (US) | 1986-10-22 | — | — | EP | claimed |
| EP-0109232-B1 | SORBINAL BY OPTICAL RESOLUTION OF PRECURSOR 6-FLURO-4-UREIDOCHROMAN-4-CARBOXYLIC ACID | PFIZER INC. (US) | 1986-10-22 | — | — | EP | claimed |
| EP-0173522-A2 | Process and intermediates for sorbinil | PFIZER INC. (US) | 1986-03-05 | — | — | EP | claimed |
| EP-0172719-A1 | Process for the production as asymmetric hydantoins | PFIZER INC. (US) | 1986-02-26 | — | — | EP | claimed |
| EP-0109232-A1 | Sorbinal by optical resolution of precursor 6-fluro-4-ureidochroman-4-carboxylic acid | PFIZER INC. (US) | 1984-05-23 | — | — | EP | claimed |
| EP-0109231-A1 | Sorbinil by optical resolution with aminopinane derivatives | PFIZER INC. (US) | 1984-05-23 | — | — | EP | claimed |
| US-4435578-A | Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid | PFIZER INC. (US) | 1984-03-06 | — | — | US | claimed |