SCHEMBL1109765

SCHEMBL1109765

Nc1ccc(C#Cc2ccc3ccc4cccnc4c3n2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.48
KDM4E B2RXH2 4/20 0.48
TDP1 Q9NUW8 3/20 0.48
LMNA P02545 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
CCR1 P32246 3/20 0.48
CCR5 P51681 3/20 0.48
CCR8 P51685 3/20 0.48
TP53 P04637 2/20 0.48
HSP90AA1 P07900 2/20 0.48
TSHR P16473 2/20 0.48
HTT P42858 2/20 0.48
GMNN O75496 1/20 0.48
MMP2 P08253 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
MMP9 P14780 1/20 0.48
ALOX15 P16050 1/20 0.48
NFKB1 P19838 1/20 0.48
MMP8 P22894 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17147590 0.85 ALDH1A1 (0.49) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL15673314 0.80 CCR1 (0.43) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL18904457 0.78 CCR1 (0.44) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL18904461 0.77 CCR1 (0.40) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL484570 0.74 GRM5 (0.56) MAPTKDM4ELMNASMN1; SMN2TP53
SCHEMBL3391907 0.72 MAPT (0.57) MAPTGRM4APPGRM5KCNH2
SCHEMBL1996991 0.72 CCR1 (0.61) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL1665269 0.72 CCR1 (0.61) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL31154476 0.71 KDM4E (0.55) MAPTKDM4ETDP1LMNASMN1; SMN2
SCHEMBL12085758 0.71 KDM4E (0.55) MAPTKDM4ETDP1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8257981-B2 Lanthanide chelates and use thereof in bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2012-09-04 US claimed
US-20110111388-A1 METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES XYNTEC CHEMIE GMBH WOLFEN (DE) 2011-05-12 US claimed
EP-1732935-B1 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS SENSIENT IMAGING TECHNOLOGIES (DE) 2007-12-12 EP claimed
EP-1732935-A2 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS Sensient Imaging Technologies GmbH (DE) 2006-12-20 EP claimed
WO-2005108405-A2 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2005-11-17 WO claimed
US-8257981-B2 Lanthanide chelates and use thereof in bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2012-09-04 US disclosed
US-8257981-B2 Lanthanide chelates and use thereof in bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2012-09-04 US disclosed
US-8257981-B2 Lanthanide chelates and use thereof in bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2012-09-04 US disclosed
US-20110136242-A1 Lanthanide Chelates and Use Thereof in Bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2011-06-09 US disclosed
US-20110136242-A1 Lanthanide Chelates and Use Thereof in Bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2011-06-09 US disclosed
US-20110136242-A1 Lanthanide Chelates and Use Thereof in Bioanalysis SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2011-06-09 US disclosed
US-20110111388-A1 METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES XYNTEC CHEMIE GMBH WOLFEN (DE) 2011-05-12 US disclosed
EP-2279415-A1 METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES Xyntec Chemie Gmbh Wolfen (DE) 2011-02-02 EP disclosed
WO-2009095189-A1 METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES XYNTEC CHEMIE GMBH WOLFEN (DE) 2009-08-06 WO disclosed
EP-1732935-B1 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS SENSIENT IMAGING TECHNOLOGIES (DE) 2007-12-12 EP disclosed
EP-1732935-B1 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS SENSIENT IMAGING TECHNOLOGIES (DE) 2007-12-12 EP disclosed
EP-1732935-A2 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS Sensient Imaging Technologies GmbH (DE) 2006-12-20 EP disclosed
WO-2005108405-A2 LANTHANIDE CHELATES AND USE THEREOF IN BIOANALYSIS SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2005-11-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136242-A1 Lanthanide Chelates and Use Thereof in Bioanalysis LANCL2, LANCL1, SSB MAPT 4811/4885KDM4E 2885/4885TDP1 3965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.