SCHEMBL11097683

SCHEMBL11097683

Cc1cc(N=C=O)cc(N=C=O)c1.O=C=Nc1ccc(Cc2ccc(N=C=O)cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.71
TSHR P16473 1/20 0.71
CYP1A2 P05177 1/20 0.57
TRPA1 O75762 1/20 0.44
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
IDH1 O75874 7/20 0.34
P2RY6 Q15077 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
SRD5A2 P31213 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
SAE1 Q9UBE0 1/20 0.31
UBA2 Q9UBT2 1/20 0.31
KMT2A Q03164 1/20 0.31
ERN1 O75460 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11271591 0.87 CYP3A4 (0.80) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL10304668 0.87 CYP3A4 (0.80) CYP3A4TSHRCYP1A2TRPA1MAPK1
Ethane SCHEMBL20537385 0.85 CYP3A4 (0.91) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL12852256 0.84 CYP3A4 (1.00) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL1396496 0.84 CYP3A4 (1.00) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL19943 0.84 CYP3A4 (1.00) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL2044965 0.84 CYP3A4 (1.00) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL22966416 0.83 CYP3A4 (0.80) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL22966371 0.83 CYP3A4 (0.87) CYP3A4TSHRCYP1A2TRPA1MAPK1
SCHEMBL30634516 0.82 CYP3A4 (0.95) CYP3A4TSHRCYP1A2TRPA1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4429000-A POLYURETHANE ELASTOMER, WATER REPELLANT, POLYISOCYANATE AND NONIONIC SURFACTANT TORAY INDUSTRIES, INC. (JP) 1984-01-31 US disclosed