Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11098511 | 1.00 | KMT2A (0.48) | KMT2ALMNAFFAR1NPC1MAPT | |
| SCHEMBL6780957 | 0.86 | GPR35 (0.51) | KMT2AFFAR1NPC1MAPTALDH1A1 | |
| SCHEMBL6780953 | 0.86 | GPR35 (0.51) | KMT2AFFAR1NPC1MAPTALDH1A1 | |
| SCHEMBL1818855 | 0.82 | MAPT (0.41) | KMT2ALMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL1818853 | 0.82 | MAPT (0.41) | KMT2ALMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL1818854 | 0.82 | MAPT (0.41) | KMT2ALMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL29302342 | 0.79 | MAPK1 (0.46) | KMT2ALMNAFFAR1MAPTALDH1A1 | |
| SCHEMBL29136832 | 0.79 | MAPK1 (0.46) | KMT2ALMNAFFAR1MAPTALDH1A1 | |
| SCHEMBL29302352 | 0.76 | SLC9A1 (0.42) | KMT2ALMNAFFAR1MAPTALDH1A1 | |
| SCHEMBL11126705 | 0.76 | ALDH1A1 (0.46) | KMT2ALMNANPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047119-B1 | CARBOXAMIDE COMPOUNDS AS SRS-A ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION, AND INTERMEDIATES USEFUL THEREIN | PFIZER INC. (US) | 1984-05-09 | — | — | EP | disclosed |
| US-4343813-A | ANTIANAPHYLACTIC AGENTS | PFIZER INC. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4331683-A | SENSITIZATION, ANTIALLERGENS | PFIZER INC. (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0047119-A1 | Carboxamide compounds as SRS-A antagonists, pharmaceutical compositions containing them, processes for the preparation, and intermediates useful therein | PFIZER INC. (US) | 1982-03-10 | — | — | EP | disclosed |