Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11124022 | 0.86 | CYP19A1 (0.45) | CYP19A1PRMT5WDR77ALDH1A1GRK6 | |
| SCHEMBL11102756 | 0.83 | CYP19A1 (0.47) | CYP19A1EIF4EIDO1LMNAGAA | |
| SCHEMBL11100404 | 0.80 | HTR2B (0.55) | CYP19A1HTR2BGAAKDM4ENPC1 | |
| SCHEMBL9823942 | 0.78 | ALDH1A1 (0.63) | CYP19A1PRMT5WDR77ALDH1A1CSNK2A1 | |
| SCHEMBL11042509 | 0.77 | ALDH1A1 (0.61) | CYP19A1PRMT5WDR77ALDH1A1CSNK2A1 | |
| SCHEMBL11042587 | 0.77 | ALDH1A1 (0.61) | CYP19A1PRMT5WDR77ALDH1A1CSNK2A1 | |
| SCHEMBL11103900 | 0.77 | CYP19A1 (0.38) | CYP19A1PRMT5WDR77ALDH1A1GRK6 | |
| SCHEMBL27899614 | 0.76 | POLB (0.40) | CYP19A1PRMT5WDR77ALDH1A1EIF4E | |
| SCHEMBL11042549 | 0.73 | CYP19A1 (0.48) | CYP19A1PRMT5WDR77ALDH1A1GRK6 | |
| SCHEMBL11125747 | 0.72 | ALOX5 (0.54) | CYP19A1ALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033151-B1 | HYDROXYPHENYL-THIAZOLE-THIAZOLINE AND -THIAZOLIDINE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND THESE COMPOUNDS FOR USE IN INFLUENCING THE COLLAGEN METABOLISM | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-05-02 | — | — | EP | disclosed |
| EP-0033151-A1 | Hydroxyphenyl-thiazole-thiazoline and -thiazolidine carboxylic acids, process for their preparation and these compounds for use in influencing the collagen metabolism | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-05 | — | — | EP | disclosed |