Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.77 |
| ▸ | CTSG | P08311 | 1/20 | 0.77 |
| ▸ | CEL | P19835 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 12/20 | 0.51 |
| ▸ | CA2 | P00918 | 6/20 | 0.51 |
| ▸ | CA12 | O43570 | 14/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439955 | 0.87 | ELANE (1.00) | ELANECTSGCELLMNACA9 | |
| SCHEMBL11094946 | 0.78 | CA12 (0.57) | ELANECTSGCELLMNACA9 | |
| SCHEMBL6903338 | 0.77 | HPGD (0.58) | ELANECTSGCELLMNACA9 | |
| SCHEMBL30367636 | 0.77 | HPGD (0.58) | ELANECTSGCELLMNACA9 | |
| SCHEMBL11574405 | 0.76 | LMNA (0.75) | ELANECTSGCELLMNACA9 | |
| Hydrogen Sulfide SCHEMBL29165723 | 0.75 | HPGD (0.57) | ELANECTSGCELLMNACA9 | |
| SCHEMBL29165709 | 0.73 | LMNA (0.51) | ELANECTSGCELLMNACA9 | |
| SCHEMBL29386930 | 0.72 | CA9 (0.60) | ELANELMNACA9CA2CA12 | |
| SCHEMBL358829 | 0.72 | CA9 (0.60) | ELANELMNACA9CA2CA12 | |
| Saccharin Calcium SCHEMBL29394622 | 0.72 | CA9 (0.60) | ELANECTSGCELLMNACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4276298-A | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors | MERCK & CO., INC. (US) | 1981-06-30 | — | — | US | claimed |
| EP-0026791-B1 | 2-ARYL-1,2-BENZISOTHIAZOLINONE-1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1984-05-02 | — | — | EP | disclosed |
| US-4369183-A | 2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors | MERCK & CO., INC. (US) | 1983-01-18 | — | — | US | disclosed |
| US-4276298-A | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors | MERCK & CO., INC. (US) | 1981-06-30 | — | — | US | disclosed |
| EP-0026791-A1 | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |