Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.68 |
| ▸ | PNMT | P11086 | 2/20 | 0.54 |
| ▸ | CD44 | P16070 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HK1 | P19367 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094326 | 0.89 | PNMT (0.65) | HTR2CPNMTCD44MAOBNPC1 | |
| SCHEMBL407439 | 0.85 | NPC1 (0.70) | HTR2CNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL5739939 | 0.82 | HTR2C (0.62) | HTR2CPNMTCD44MAOBNPC1 | |
| SCHEMBL175146 | 0.82 | HTR2C (1.00) | HTR2CPNMTCD44MAOBDRD2 | |
| SCHEMBL4861947 | 0.80 | MAPT (0.72) | MAOBNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL5741556 | 0.80 | NPC1 (0.63) | HTR2CPNMTCD44MAOBNPC1 | |
| SCHEMBL23555058 | 0.79 | HTR2C (0.94) | HTR2CPNMTCD44MAOBDRD2 | |
| Ammonia Solution, Strong SCHEMBL20359164 | 0.79 | HTR2C (0.94) | HTR2CPNMTCD44MAOBDRD2 | |
| Hydrochloric Acid SCHEMBL2307798 | 0.79 | HTR2C (0.94) | HTR2CPNMTCD44MAOBGAA | |
| Indoline SCHEMBL27677476 | 0.79 | HTR2C (0.58) | HTR2CPNMTCD44MAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057777-B1 | DIBENZOXAZONINE, DIBENZOXAZECINE, DIBENZOXAAZACYCLOUNDECANE DERIVATIVES AND THEIR CORRESPONDING THIA- AND AZA DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-10 | — | — | EP | disclosed |