Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.62 |
| ▸ | PNMT | P11086 | 2/20 | 0.50 |
| ▸ | CD44 | P16070 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indoline SCHEMBL27677476 | 0.93 | HTR2C (0.58) | HTR2CPNMTCD44MAOBALOX15 | |
| SCHEMBL23555059 | 0.88 | HTR2C (0.58) | HTR2CPNMTCD44MAOBALOX15 | |
| Naphthalene SCHEMBL28125430 | 0.88 | HTR2C (0.52) | HTR2CPNMTCD44MAOBALOX15 | |
| SCHEMBL8896060 | 0.88 | HTR2C (0.46) | HTR2CPNMTCD44MAOBALOX15 | |
| Indoline SCHEMBL5629 | 0.86 | — | — | |
| Indoline SCHEMBL29360339 | 0.86 | — | — | |
| Indoline SCHEMBL28244360 | 0.86 | HTR2C (0.50) | HTR2CPNMTCD44MAOBALOX15 | |
| Indoline SCHEMBL29002623 | 0.85 | HTR2C (0.54) | HTR2CPNMTCD44MAOBALOX15 | |
| Piperazine SCHEMBL28330011 | 0.85 | HTR2C (0.48) | HTR2CPNMTCD44MAOBALOX15 | |
| Indoline SCHEMBL8194348 | 0.84 | HTR2C (0.50) | HTR2CPNMTCD44MAOBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497296-B1 | [1,4]DIAZOCINO[7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH CORP (US) | 2006-03-22 | — | — | EP | disclosed |
| US-7012089-B2 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH (US) | 2006-03-14 | — | — | US | disclosed |
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | HTR1A, HTR2C, HTR1D | HTR2C 2/4885PNMT 387/4885CD44 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.