Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 8/20 | 0.40 |
| ▸ | ME2 | P23368 | 1/20 | 0.35 |
| ▸ | ME1 | P48163 | 1/20 | 0.35 |
| ▸ | ME3 | Q16798 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31087413 | 0.85 | ESR1 (0.44) | ESR1ESR2DEGS1CA2 | |
| SCHEMBL7229581 | 0.82 | RAB9A (0.44) | — | |
| SCHEMBL4178273 | 0.81 | CA2 (0.50) | ESR1ESR2DEGS1ME2ME1 | |
| SCHEMBL26046019 | 0.80 | TDP1 (0.51) | — | |
| SCHEMBL1979245 | 0.80 | RAB9A (0.40) | — | |
| SCHEMBL30728065 | 0.80 | ADRA2A (0.40) | ESR1ESR2CA2 | |
| SCHEMBL13754672 | 0.80 | KDM4E (0.46) | — | |
| SCHEMBL27960128 | 0.80 | ESR1 (0.32) | ESR1ESR2 | |
| SCHEMBL28383321 | 0.79 | ESR1 (0.44) | ESR1ESR2DEGS1ME2ME1 | |
| SCHEMBL24760581 | 0.79 | HRH3 (0.45) | DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797889-A1 | NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Centaurus Biopharma Co., Ltd. (CN) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097773-A1 | NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2013-07-04 | — | — | WO | disclosed |
| EP-0019739-B1 | 2-AMINOALKYL-5-PYRIDINOLES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1984-07-18 | — | — | EP | disclosed |
| US-4260619-A | ANTIISCHEMIC | CIBA-GEIGY CORPORATION (US) | 1981-04-07 | — | — | US | disclosed |
| EP-0019739-A1 | 2-Aminoalkyl-5-pyridinoles, process for their preparation and pharmaceutical preparations containing them | CIBA-GEIGY AG (CH) | 1980-12-10 | — | — | EP | disclosed |