Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Furosemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | CA12 | O43570 | 2/20 | 0.98 |
| ▸ | CA1 | P00915 | 2/20 | 0.98 |
| ▸ | CA2 | P00918 | 2/20 | 0.98 |
| ▸ | CA6 | P23280 | 2/20 | 0.98 |
| ▸ | CA5A | P35218 | 2/20 | 0.98 |
| ▸ | CA7 | P43166 | 2/20 | 0.98 |
| ▸ | CA9 | Q16790 | 2/20 | 0.98 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.98 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | CA4 | P22748 | 1/20 | 0.98 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.98 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.98 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.98 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.98 |
| ▸ | APP | P05067 | 9/20 | 0.75 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furosemide SCHEMBL29406913 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL428921 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL9811 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL11319593 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10867860 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10339959 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2953945 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2519788 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL9183914 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL8092440 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546985-B2 | Electromagnetic motor and equipment to generate work torque | ASSOCIACAO KEPPE & PACHECO (BR) | 2013-10-01 | — | — | US | disclosed |
| EP-2279552-A2 | ELECTROMAGNETIC MOTOR AND EQUIPMENT TO GENERATE WORK TORQUE | Associação Keppe & Pacheco (BR) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009140750-A2 | ELECTROMAGNETIC MOTOR AND EQUIPMENT TO GENERATE WORK TORQUE | ASSOCIAÇÃO KEPPE & PACHECO (BR) | 2009-11-26 | — | — | WO | disclosed |