Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Furosemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | CA12 | O43570 | 2/20 | 0.98 |
| ▸ | CA1 | P00915 | 2/20 | 0.98 |
| ▸ | CA2 | P00918 | 2/20 | 0.98 |
| ▸ | CA6 | P23280 | 2/20 | 0.98 |
| ▸ | CA5A | P35218 | 2/20 | 0.98 |
| ▸ | CA7 | P43166 | 2/20 | 0.98 |
| ▸ | CA9 | Q16790 | 2/20 | 0.98 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.98 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | CA4 | P22748 | 1/20 | 0.98 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.98 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.98 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.98 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.98 |
| ▸ | APP | P05067 | 9/20 | 0.75 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Furosemide SCHEMBL428921 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL29406913 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL9811 | 0.99 | CISD1 (1.00) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL6325856 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10867860 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL10339959 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL11898462 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL1109955 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL2519788 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 | |
| Furosemide SCHEMBL6751172 | 0.98 | CISD1 (0.98) | CISD1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-214900597-U | Winding device for motor iron core | 山东信力德动力科技有限公司 | 2021-11-26 | — | — | CN | claimed |
| CN-210535476-U | Low-leakage-reactance high-frequency transformer | 湖南工程学院 | 2020-05-15 | — | — | CN | claimed |
| CN-110344590-A | A kind of Screw arbor with nut at both-ends and its construction method | 中国十七冶集团有限公司 | 2019-10-18 | — | — | CN | claimed |
| CN-109347226-A | A kind of bearing-free permanent magnet thin-sheet motor | 江苏大学 | 2019-02-15 | — | — | CN | claimed |
| CN-108887188-A | A kind of agricultural breeding device for feeding with storing function | 苏州浔宇新材料科技有限公司 | 2018-11-27 | — | — | CN | claimed |
| CN-103326527-B | Brushless motor | 阿斯莫有限公司 | 2018-03-20 | — | — | CN | claimed |
| CN-206630495-U | Food cooking machine | 广东美的生活电器制造有限公司 | 2017-11-14 | — | — | CN | claimed |
| CN-205877964-U | Street lamp is used in park | 扬州市国光照明集团有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-103962883-B | The dynamic absorber lathe tool of mode of operation is extruded based on magnetic flow liquid | 上海理工大学 | 2016-06-08 | — | — | CN | claimed |
| CN-105240443-A | Semi-active turning flutter magneto-rheological damping device based on extrusion operation mode | UNIV SHANGHAI SCIENCE & TECH | 2016-01-13 | — | — | CN | claimed |
| CN-203039939-U | Electric heating plate | GUAN JIANDONG | 2013-07-03 | — | — | CN | claimed |
| CN-202326288-U | Variable frequency speed-increasing deep well submersible pump | TAIZHOU BAISHIDU INDUSTRY TRADE CO LTD | 2012-07-11 | — | — | CN | claimed |
| CN-202152578-U | Elastic door stopper | CHANGMAO ZHANG | 2012-02-29 | — | — | CN | claimed |
| CN-100486083-C | DC motor | ASABA K K (JP) | 2009-05-06 | — | — | CN | claimed |
| CN-2904716-Y | Hanging ring | LI YUNFU (CN) | 2007-05-30 | — | — | CN | claimed |
| CN-1937389-A | Magnetic machine | DONG XINWU (CN) | 2007-03-28 | — | — | CN | claimed |
| CN-2680943-Y | Disc iron core type bistable solenoid valve | LIU BAOYING (CN) | 2005-02-23 | — | — | CN | claimed |
| CN-1411133-A | Magnetic motor | DONG XINWU (CN) | 2003-04-16 | — | — | CN | claimed |
| CN-2351129-Y | Electric-heating medicine health kettle | FAN CHUTING (CN) | 1999-12-01 | — | — | CN | claimed |
| CN-85203304-U | PLATE-SHAPED ELECTRIC MOTOR | — | 1986-07-23 | — | — | CN | claimed |