Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094841 | 0.88 | AR (0.50) | ARLMNATP53RAB9APOLB | |
| SCHEMBL11092968 | 0.85 | HPGDS (0.49) | HPGDSTSHRLMNASMN1; SMN2RAB9A | |
| Water SCHEMBL11097766 | 0.84 | HPGDS (0.48) | HPGDSTSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL4415107 | 0.79 | AR (0.55) | ARHPGDSTSHRLMNASMN1; SMN2 | |
| SCHEMBL2733465 | 0.78 | POLB (0.60) | HPGDSTSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL14190001 | 0.74 | SMN1; SMN2 (0.53) | ARHPGDSTSHRLMNASMN1; SMN2 | |
| SCHEMBL4418297 | 0.74 | HPGDS (0.51) | ARHPGDSTSHRLMNASMN1; SMN2 | |
| SCHEMBL11102018 | 0.73 | PTGDR2 (0.53) | ARLMNAMAPTRAB9APLA2G2A | |
| SCHEMBL5327448 | 0.73 | AR (0.53) | ARLMNAMAPTRAB9APLA2G2A | |
| SCHEMBL2789865 | 0.72 | CYP2C19 (0.58) | TSHRLMNASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028833-B1 | IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-25 | — | — | EP | disclosed |
| US-4340598-A | Hypotensive imidazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0028833-A2 | Imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |