Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486964 | 0.87 | BRD4 (0.53) | ALDH1A1BRD4MEN1KMT2ADRD2 | |
| SCHEMBL21460278 | 0.76 | SLC6A4 (0.53) | HTR2CHTR2BALDH1A1BRD4MEN1 | |
| SCHEMBL24260258 | 0.74 | KDM4E (0.49) | KDM4EMEN1KMT2ADRD2 | |
| SCHEMBL3715263 | 0.73 | BCHE (0.55) | HTR6HTR2CHTR2BALDH1A1EHMT2 | |
| SCHEMBL8487979 | 0.73 | ACHE (0.69) | GAAALDH1A1HSD17B10EHMT2NSD2 | |
| SCHEMBL3715268 | 0.72 | ACHE (0.47) | HTR6HTR2CHTR2BALDH1A1KDM4E | |
| SCHEMBL26268468 | 0.71 | POLB (0.49) | HTR2CGAAALDH1A1BRD4NSD2 | |
| SCHEMBL14783954 | 0.71 | HRH3 (0.47) | EHMT2MEN1KMT2A | |
| SCHEMBL24260259 | 0.71 | SSTR4 (0.46) | KDM4EMEN1KMT2ADRD2 | |
| SCHEMBL29227078 | 0.71 | KMT2A (0.50) | HTR6HTR2CHTR2BGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0026469-B1 | DIBENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1984-11-28 | — | — | EP | disclosed |
| US-4360525-A | NEUROLEPTIC AGENTS, ANTIDEPRESSANTS, SLEEP PROMOTERS | SANDOZ LTD. (CH) | 1982-11-23 | — | — | US | disclosed |
| EP-0026469-A1 | Dibenzazepine derivatives, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-04-08 | — | — | EP | disclosed |