Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401906 | 0.88 | CASR (0.47) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL11390883 | 0.88 | ALDH1A1 (0.57) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL11555116 | 0.88 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL8134460 | 0.86 | AR (0.48) | ALDH1A1KDM4ELMNAHPGDRAB9A | |
| SCHEMBL11105634 | 0.85 | KDM4E (0.39) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL11166790 | 0.80 | ALDH1A1 (0.49) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL8957207 | 0.77 | ALDH1A1 (0.49) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL6967064 | 0.75 | ALDH1A1 (0.51) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL11254294 | 0.74 | ALDH1A1 (0.46) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E | |
| SCHEMBL2834778 | 0.72 | ALDH1A1 (0.45) | ALDH1A1PDE6DALDH2ALDH3A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028833-B1 | IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-25 | — | — | EP | disclosed |
| US-4340598-A | Hypotensive imidazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0028833-A2 | Imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |
| EP-0005528-A2 | Imidazole derivatives, their preparation and pharmaceutical compositions | Takeda Chemical Industries, Ltd. (JP) | 1979-11-28 | — | — | EP | disclosed |
| US-4162314-A | ANTIBIOTICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-07-24 | — | — | US | disclosed |