SCHEMBL11254294

SCHEMBL11254294

O=C([O-])Cc1nc(-c2ccccc2)n(Cc2ccccc2)c1Cl.[Na+]

nearest known ligand 0.46

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.46
LMNA P02545 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
RECQL P46063 1/20 0.46
RAB9A P51151 1/20 0.46
PDE6D O43924 2/20 0.46
ALDH2 P05091 1/20 0.46
ALDH3A1 P30838 1/20 0.46
BCL2 P10415 1/20 0.44
MCL1 Q07820 1/20 0.44
HPGD P15428 4/20 0.43
KDM4E B2RXH2 4/20 0.43
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
TP53 P04637 2/20 0.39
MAPK1 P28482 1/20 0.39
GAA P10253 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957207 0.88 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
Hydrochloric Acid SCHEMBL11095632 0.80 ALDH1A1 (0.51) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL6967064 0.80 ALDH1A1 (0.51) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL11099962 0.74 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL8125624 0.73 AR (0.57) ALDH1A1LMNARAB9AHPGDKDM4E
SCHEMBL8954292 0.71 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
SCHEMBL8131797 0.71 AR (0.52) ALDH1A1LMNARAB9AHPGDKDM4E
SCHEMBL7054371 0.70 ALDH1A1 (0.48) ALDH1A1LMNASMN1; SMN2RECQLRAB9A
Oxalic Acid SCHEMBL2838926 0.70 ALDH1A1 (0.44) ALDH1A1LMNASMN1; SMN2KDM4EKMT2A
SCHEMBL11099710 0.69 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2RECQLRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4340598-A Hypotensive imidazole derivatives TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1982-07-20 US disclosed