SCHEMBL6967064

SCHEMBL6967064

O=C(O)CCc1nc(-c2ccccc2)n(Cc2ccccc2)c1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.51
KDM4E B2RXH2 5/20 0.51
HTT P42858 1/20 0.50
SMN1; SMN2 Q16637 3/20 0.47
LMNA P02545 3/20 0.47
RECQL P46063 1/20 0.47
RAB9A P51151 1/20 0.47
PDE6D O43924 1/20 0.47
ALDH2 P05091 1/20 0.47
ALDH3A1 P30838 1/20 0.47
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TP53 P04637 1/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
KEAP1 Q14145 1/20 0.44
FFAR1 O14842 2/20 0.43
BCL2 P10415 1/20 0.43
MCL1 Q07820 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8957207 0.86 ALDH1A1 (0.49) ALDH1A1KDM4ESMN1; SMN2LMNARECQL
SCHEMBL11254294 0.80 ALDH1A1 (0.46) ALDH1A1KDM4ESMN1; SMN2LMNARECQL
Hydrochloric Acid SCHEMBL11095632 0.76 ALDH1A1 (0.51) ALDH1A1SMN1; SMN2LMNARECQLRAB9A
SCHEMBL11099962 0.75 ALDH1A1 (0.49) ALDH1A1KDM4EHTTSMN1; SMN2LMNA
SCHEMBL8954292 0.72 ALDH1A1 (0.49) ALDH1A1KDM4ESMN1; SMN2LMNARECQL
Oxalic Acid SCHEMBL2838926 0.71 ALDH1A1 (0.44) ALDH1A1KDM4ESMN1; SMN2LMNAHSD17B10
SCHEMBL8125624 0.71 AR (0.57) ALDH1A1KDM4EHTTLMNARAB9A
SCHEMBL11099710 0.69 ALDH1A1 (0.49) ALDH1A1KDM4ESMN1; SMN2LMNARECQL
SCHEMBL8131797 0.69 AR (0.52) ALDH1A1KDM4EHTTLMNARAB9A
SCHEMBL8823072 0.69 ALDH1A1 (0.51) ALDH1A1KDM4ESMN1; SMN2LMNARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0955294-B1 Imidazolyl-alkenoic acid SMITHKLINE BEECHAM CORP (US) 2003-09-24 EP disclosed
EP-0641203-B1 PHARMACEUTICAL COMPOSITIONS OF AN IMIDAZOLYL-AKENOIC ACID SALT AND THEIR USE AS ANGIOTENSIN II ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-10-16 EP disclosed
EP-0563238-B1 IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORP (US) 2002-05-22 EP disclosed
EP-0403159-B1 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORP (US) 2000-03-01 EP disclosed
CN-1048159-C Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORP (US) 2000-01-12 CN disclosed
EP-0955294-A2 Imidazolyl-alkenoic acid SMITHKLINE BEECHAM CORPORATION (US) 1999-11-10 EP disclosed
US-5929249-A ANGIOTENSIN II RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-07-27 US disclosed
US-5728842-A ANGIOTENSIN II RECEPTOR ANTAGONIST SMITHKLINE BEECHAM CORPORATION (US) 1998-03-17 US disclosed
CN-1036396-C Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORP (US) 1997-11-12 CN disclosed
US-5447949-A Vision defects or cardiovascular disorders SMITHKLINE BEECHAM CORPORATION (US) 1995-09-05 US disclosed
US-5185351-A Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma SMITHKLINE BEECHAM CORPORATION (US) 1993-02-09 US disclosed
US-5177096-A Angiotensin II receptor antagonist SMITHKLINE BEECHAM CORPORATION (US) 1993-01-05 US disclosed
WO-1992020651-A2 N-(HETEROARYL)-IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORPORATION (US) 1992-11-26 WO disclosed
WO-1992010189-A1 IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORPORATION (US) 1992-06-25 WO disclosed
WO-1992009278-A1 SUBSTITUTED 5-ARYL IMIDAZOLES SMITHKLINE BEECHAM CORPORATION (US) 1992-06-11 WO disclosed
EP-0425211-A1 Substituted 5-((tetrazolyl)alkenyl)-imidazoles SMITHKLINE BEECHAM CORPORATION (US) 1991-05-02 EP disclosed
CN-1048038-A IMIDAZOLYL-ALKENOIC ACIDS SMITHKLINE BEECHAM CORP (US) 1990-12-26 CN disclosed
CN-1048039-A Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORP (US) 1990-12-26 CN disclosed
EP-0403158-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed
EP-0403159-A2 Imidazolyl-alkenoic acids SMITHKLINE BEECHAM CORPORATION (US) 1990-12-19 EP disclosed