Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | G6PD | P11413 | 1/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28712212 | 0.88 | GAA (0.63) | KMT2AMEN1HTTGAAATM | |
| SCHEMBL10539201 | 0.87 | KMT2A (0.62) | KMT2AMEN1HTTALDH1A1AGTR1 | |
| SCHEMBL11673189 | 0.87 | ALDH1A1 (0.54) | KMT2AMEN1HTTGAAALDH1A1 | |
| SCHEMBL6158148 | 0.87 | KMT2A (0.57) | KMT2AMEN1HTTGAAATM | |
| SCHEMBL28852443 | 0.85 | NPC1 (0.55) | KMT2AMEN1HTTGAAALDH1A1 | |
| Malonic Acid Diethyl Ester SCHEMBL27871201 | 0.85 | MEN1 (0.58) | KMT2AMEN1HTTGAAATM | |
| SCHEMBL10806282 | 0.83 | ATM (0.55) | KMT2AMEN1HTTGAAATM | |
| SCHEMBL11760069 | 0.83 | ALDH1A1 (0.51) | KMT2AMEN1HTTALDH1A1AGTR1 | |
| SCHEMBL276340 | 0.82 | LMNA (0.59) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL3388760 | 0.82 | NPC1 (0.62) | KMT2AMEN1HTTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101429183-A | 2H-1-benzopyran-2-ketone compounds with alpha-glucosidase inhibit activity, its composition and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-05-13 | — | — | CN | claimed |
| US-12637436-B2 | Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2026-05-26 | — | — | US | disclosed |
| US-20250230147-A1 | LACTAMS AS CBL-B INHIBITORS | GENENTECH, INC. (US) | 2025-07-17 | — | — | US | disclosed |
| EP-4563572-A1 | PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT | The Noguchi Institute (JP) | 2025-06-04 | — | — | EP | disclosed |
| US-20250129030-A1 | PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT | THE NOGUCHI INSTITUTE (JP) | 2025-04-24 | — | — | US | disclosed |
| WO-2024024760-A1 | PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT | 公益財団法人野口研究所 | 2024-02-01 | — | — | WO | disclosed |
| EP-4288429-A1 | LACTAMS AS CBL-B INHIBITORS | Genentech, Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| CN-116888112-A | Lactams as CBL-B inhibitors | 基因泰克公司 | 2023-10-13 | — | — | CN | disclosed |
| US-20230113588-A1 | METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2023-04-13 | — | — | US | disclosed |
| US-20230079990-A1 | LACTAMS AS CBL-B INHIBITORS | GENENTECH, INC. (US) | 2023-03-16 | — | — | US | disclosed |
| EP-0946528-A2 | OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028282-A2 | OXYGEN OR SULFUR CONTAINING 5-MEMBERED HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |
| EP-0620818-A1 | ARYL KETONES AS TESTOSTERONE 5$g(a)-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993013099-A1 | ARYL KETONES AS TESTOSTERONE 5α-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-08 | — | — | WO | disclosed |
| US-4692447-A | HYPOTENSIVE, VASODILATOR, ANTITHROMBOTIC, ANTIAGGREGANT, CYTOPROTECTIVE | BOEHRINGER BIOCHEMIA ROBIN, S.P.A. (IT) | 1987-09-08 | — | — | US | disclosed |
| EP-0169443-A2 | Tricyclic dihydropyridazinones and pharmaceutical compositions contaning them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-01-29 | — | — | EP | disclosed |
| EP-0015602-B1 | NOVEL LIGHT-ABSORBING METHINE DYES AND PHOTOGRAPHIC MATERIALS CONTAINING THEM | AGFA-GEVAERT N.V. (BE) | 1983-09-21 | — | — | EP | disclosed |
| US-4266014-A | Photographic materials containing light absorbing methine dyes | AGFA-GEVAERT N.V. (BE) | 1981-05-05 | — | — | US | disclosed |
| EP-0015602-A1 | Novel light-absorbing methine dyes and photographic materials containing them | AGFA-GEVAERT N.V. (BE) | 1980-09-17 | — | — | EP | disclosed |
| US-4041158-A | INSECTICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250230147-A1 | LACTAMS AS CBL-B INHIBITORS | CBLB, CBL, CBLC | KMT2A 1976/4885MEN1 2646/4885HTT 4101/4885 |
| US-20230113588-A1 | METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF | GRM3, GRM2, GRM1 | KMT2A 942/4885MEN1 2740/4885HTT 1571/4885 |
| US-20230079990-A1 | LACTAMS AS CBL-B INHIBITORS | CBLB, CBL, CBLC | KMT2A 1976/4885MEN1 2646/4885HTT 4101/4885 |
| US-20250129030-A1 | PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT | NPM1, PLK3, PKN2 | KMT2A 3718/4885MEN1 3460/4885HTT 2453/4885 |
| US-12637436-B2 | Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof | GRM3, GRM2, GRM1 | KMT2A 1325/4885MEN1 2193/4885HTT 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.