Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 6/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9746964 | 0.88 | HSD17B1 (0.66) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL9634078 | 0.88 | LMNA (0.66) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL10531128 | 0.88 | LMNA (0.66) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL6468077 | 0.86 | LMNA (0.64) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL6465770 | 0.86 | LMNA (0.64) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL11101794 | 0.86 | LMNA (0.64) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL13930475 | 0.86 | AKR1C3 (0.61) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL17525935 | 0.85 | LMNA (0.62) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL14569770 | 0.84 | HSD17B10 (0.70) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 | |
| SCHEMBL13930476 | 0.84 | HSD17B10 (0.70) | HSD17B1LMNAMAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044105-B1 | NEW 8-ALPHA-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-03 | — | — | EP | claimed |
| EP-0044105-B1 | NEW 8-ALPHA-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-03 | — | — | EP | disclosed |
| US-4407753-A | 8α-Oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1983-10-04 | — | — | US | disclosed |
| EP-0044105-A2 | New 8-alpha-oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1982-01-20 | — | — | EP | disclosed |