Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982615 | 1.00 | ALDH1A1 (0.46) | ALDH1A1CA1CA2CA4EPHX1 | |
| SCHEMBL23139037 | 1.00 | ALDH1A1 (0.46) | ALDH1A1CA1CA2CA4EPHX1 | |
| SCHEMBL11103013 | 1.00 | ALDH1A1 (0.46) | ALDH1A1CA1CA2CA4EPHX1 | |
| SCHEMBL13311938 | 0.98 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA4EPHX1 | |
| SCHEMBL9439785 | 0.94 | ALDH1A1 (0.41) | ALDH1A1CA1CA2CA4 | |
| SCHEMBL24699834 | 0.85 | ALDH1A1 (0.50) | ALDH1A1EPHX1 | |
| SCHEMBL330951 | 0.84 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL9323923 | 0.82 | ALDH1A1 (0.57) | ALDH1A1EPHX1 | |
| SCHEMBL5460574 | 0.82 | ALDH1A1 (0.57) | ALDH1A1EPHX1 | |
| SCHEMBL26012 | 0.82 | ALDH1A1 (0.57) | ALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250223263-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NodThera Limited (GB) | 2025-07-10 | — | — | US | disclosed |
| US-12247011-B2 | Selective inhibitors of NLRP3 inflammasome | NodThera Limited (GB) | 2025-03-11 | — | — | US | disclosed |
| CN-111356680-B | Selective inhibitors of NLRP3 inflammasome | 诺瑟拉有限公司 | 2023-11-28 | — | — | CN | disclosed |
| EP-3661921-B1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NODTHERA LTD (GB) | 2023-10-18 | — | — | EP | disclosed |
| US-20210087147-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NodThera Limited (GB) | 2021-03-25 | — | — | US | disclosed |
| CN-111356680-A | Selective inhibitors of NLRP3inflammasome | 诺瑟拉有限公司 | 2020-06-30 | — | — | CN | disclosed |
| US-4442116-A | MITICIDES | NIPPON SODA COMPANY, LIMITED (JP) | 1984-04-10 | — | — | US | disclosed |
| US-4431814-A | HERBICIDES, MITICIDES, ANTICONVULSANTS | NIPPON SODA COMPANY LIMITED (JP) | 1984-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12247011-B2 | Selective inhibitors of NLRP3 inflammasome | NLRP3, NOD1, NLRP1 | ALDH1A1 961/4885CA1 3844/4885CA2 3927/4885 |
| US-20250223263-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NLRP3, NOD1, NLRP1 | ALDH1A1 961/4885CA1 3844/4885CA2 3927/4885 |
| US-20210087147-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NLRP3, NOD1, NLRP1 | ALDH1A1 961/4885CA1 3844/4885CA2 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.