Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.46 |
| ▸ | KRAS | P01116 | 4/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11106600 | 0.89 | PIK3CD (0.39) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11105125 | 0.83 | EGFR (0.48) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11110469 | 0.82 | EGFR (0.47) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11105460 | 0.80 | GALR3 (0.54) | EGFRKRASSOS1 | |
| SCHEMBL11103664 | 0.79 | ALDH1A1 (0.49) | EGFRKRASSOS1P2RX3 | |
| SCHEMBL11103785 | 0.79 | EGFR (0.43) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11126373 | 0.78 | EGFR (0.48) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11100849 | 0.76 | ALDH1A1 (0.43) | EGFRPIK3CDKDM4E | |
| SCHEMBL11105547 | 0.76 | EGFR (0.37) | EGFRKRASSOS1P2RX3PIK3CD | |
| SCHEMBL11104793 | 0.75 | PIK3CD (0.41) | EGFRP2RX3PIK3CDPIK3R2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |