Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | PYGL | P06737 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11109699 | 1.00 | MTNR1A (0.34) | MTNR1AMTNR1BCNR1SIGMAR1PYGL | |
| SCHEMBL11109702 | 1.00 | MTNR1A (0.34) | MTNR1AMTNR1BCNR1SIGMAR1PYGL | |
| SCHEMBL11117091 | 0.77 | ALDH1A1 (0.33) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL10669378 | 0.65 | MTNR1A (0.40) | MTNR1AMTNR1BPYGLALDH1A1 | |
| SCHEMBL697600 | 0.62 | ALDH1A1 (0.60) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL696008 | 0.62 | ALDH1A1 (0.60) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL696007 | 0.62 | ALDH1A1 (0.60) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL697601 | 0.62 | ALDH1A1 (0.60) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7279700 | 0.62 | ALDH1A1 (0.60) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL11272560 | 0.59 | ALDH1A1 (0.42) | MTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033767-B1 | INDOLOBENZOXAZINES, PROCESSES FOR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4238486-A | TREATING HYPERTENSION AND PARKINSON*S DISEASE | MERCK & CO., INC. (US) | 1980-12-09 | — | — | US | disclosed |