Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.38 |
| ▸ | AOC2 | O75106 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28450234 | 0.85 | GABRA1 (0.56) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL28450236 | 0.85 | GABRA1 (0.56) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL11285607 | 0.85 | HPGD (0.47) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL4197198 | 0.83 | CA2 (0.43) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL7336911 | 0.83 | CA2 (0.43) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL28456004 | 0.81 | HPGD (0.43) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL7804953 | 0.81 | HPGD (0.43) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL30151789 | 0.80 | HPGD (0.59) | HPGDTSHRHSP90AB1GABRA1GABRB2 | |
| SCHEMBL30151836 | 0.79 | HPGD (0.62) | HPGDTSHRGABRA1GABRB2DYRK1A | |
| SCHEMBL9810785 | 0.78 | MEN1 (0.43) | GABRA1GABRB2ARGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011818-B1 | MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE | CIBA-GEIGY AG (CH) | 1983-01-19 | — | — | EP | claimed |
| EP-0011818-A1 | Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | claimed |
| EP-0103246-A1 | 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and derivatives thereof | ABBOTT LABORATORIES (US) | 1984-03-21 | — | — | EP | disclosed |