Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750628 | 0.94 | TSHR (0.57) | SMN1; SMN2TSHRSIGMAR1ACHECHRM2 | |
| SCHEMBL11115170 | 0.93 | TSHR (0.56) | LMNAHTTSMN1; SMN2TSHRSIGMAR1 | |
| SCHEMBL11114288 | 0.90 | BCL2 (0.60) | LMNAHTTSMN1; SMN2TSHRBCL2 | |
| SCHEMBL11114118 | 0.89 | TSHR (0.52) | LMNASMN1; SMN2TSHRSIGMAR1NPSR1 | |
| SCHEMBL11109990 | 0.88 | TSHR (0.51) | SMN1; SMN2TSHRSIGMAR1ACHETMEM97 | |
| SCHEMBL11112967 | 0.82 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2TSHRBCL2SIGMAR1 | |
| SCHEMBL6320470 | 0.80 | CALM1 (0.47) | LMNAHTTSMN1; SMN2TSHRSIGMAR1 | |
| SCHEMBL11116056 | 0.79 | SMN1; SMN2 (0.53) | LMNAHTTSMN1; SMN2BCL2SIGMAR1 | |
| SCHEMBL11125959 | 0.74 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2TSHRBCL2SIGMAR1 | |
| SCHEMBL28596222 | 0.71 | SMN1; SMN2 (0.55) | LMNAHTTSMN1; SMN2GAACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041757-B1 | ETHYLENDIAMINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND INTERMEDIATES FOR THEIR PREPARATION | Simes S.p.A. (IT) | 1984-11-07 | — | — | EP | disclosed |