Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11112967 | 0.93 | SMN1; SMN2 (0.60) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11114118 | 0.90 | TSHR (0.52) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11114288 | 0.88 | BCL2 (0.60) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11115170 | 0.85 | TSHR (0.56) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11125959 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9750628 | 0.84 | TSHR (0.57) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11110419 | 0.81 | SIGMAR1 (0.55) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11116143 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11111482 | 0.79 | LMNA (0.52) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11109990 | 0.79 | TSHR (0.51) | SMN1; SMN2CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041757-B1 | ETHYLENDIAMINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND INTERMEDIATES FOR THEIR PREPARATION | Simes S.p.A. (IT) | 1984-11-07 | — | — | EP | disclosed |