SCHEMBL11111898

SCHEMBL11111898

CCOC(=O)c1ccccc1C(=O)Oc1ncc[nH]1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.58
NUDT1 P36639 1/20 0.49
ALDH1A1 P00352 3/20 0.48
HSD17B10 Q99714 1/20 0.48
HTT P42858 1/20 0.45
CLEC4M Q9H2X3 1/20 0.45
CDC25B P30305 1/20 0.45
ALK Q9UM73 1/20 0.43
MAOB P27338 1/20 0.43
TDP1 Q9NUW8 2/20 0.43
POLB P06746 1/20 0.43
JAK2 O60674 1/20 0.43
JAK3 P52333 1/20 0.43
MEN1 O00255 1/20 0.42
USP2 O75604 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.42
ALOX15 P16050 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11231296 0.87 CSNK1A1 (0.44) TSHRALDH1A1HSD17B10HTTTDP1
SCHEMBL10438254 0.84 NPC1 (0.45) HTTMEN1MAPTKMT2AL3MBTL1
SCHEMBL4879110 0.81 ALDH1A1 (0.42) TSHRALDH1A1HSD17B10TDP1MEN1
SCHEMBL24485 0.80 HPGD (0.51) TSHRALDH1A1HSD17B10TDP1POLB
SCHEMBL9667034 0.78 CSNK1A1 (0.61) TSHRNUDT1ALDH1A1HSD17B10HTT
SCHEMBL2565429 0.77 ALDH1A1 (0.40) TSHRNUDT1ALDH1A1HSD17B10CYP3A4
Diethyl Phthalate SCHEMBL22296 0.76 TSHR (1.00) TSHRALDH1A1HSD17B10CDC25BTDP1
Diethyl Phthalate SCHEMBL29404255 0.76 TSHR (1.00) TSHRALDH1A1HSD17B10CDC25BTDP1
Diethyl Phthalate SCHEMBL5306972 0.76 TSHR (1.00) TSHRALDH1A1HSD17B10CDC25BTDP1
Diethyl Phthalate SCHEMBL19252611 0.75 TSHR (0.95) TSHRALDH1A1HSD17B10CDC25BTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4440658-A TERT-ALKYL PRIMARY AMINE SALT OF ALKYLIMIDAZOLYLETHYL MONOPHTHALATE AS OIL ADDITIVE MOBIL OIL CORPORATION (US) 1984-04-03 US claimed