Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086574 | 0.94 | CTSV (0.51) | PHOSPHO1CTSVCTSLKAT2BMAPT | |
| Ethane SCHEMBL27503799 | 0.91 | CTSV (0.49) | PHOSPHO1CTSVCTSLKAT2BMAPT | |
| SCHEMBL3083218 | 0.86 | MAPT (0.55) | PHOSPHO1KAT2BMAPTSMN1; SMN2KMT2A | |
| SCHEMBL472542 | 0.85 | KDM4E (0.57) | PHOSPHO1CTSVCTSLMAPTSMN1; SMN2 | |
| SCHEMBL29724161 | 0.85 | KDM4E (0.57) | PHOSPHO1CTSVCTSLMAPTSMN1; SMN2 | |
| SCHEMBL17037091 | 0.80 | MAPT (0.49) | PHOSPHO1KAT2BMAPTSMN1; SMN2KMT2A | |
| SCHEMBL11634334 | 0.80 | TDP1 (0.47) | MAPTSMN1; SMN2KMT2AALDH1A1KDM4E | |
| Bicarbonate SCHEMBL8096275 | 0.79 | KDM4E (0.58) | MAPTSMN1; SMN2KMT2AALDH1A1HPGD | |
| Bicarbonate SCHEMBL9809601 | 0.79 | KDM4E (0.58) | MAPTSMN1; SMN2KMT2AALDH1A1HPGD | |
| Bicarbonate SCHEMBL9168209 | 0.79 | KDM4E (0.58) | MAPTSMN1; SMN2KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110833-A1 | Use of light-sensitive product mixtures for electroless metal deposition | CIBA-GEIGY AG (CH) | 1984-06-13 | — | — | EP | disclosed |