Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11007073 | 0.90 | GAA (0.59) | GAAMAPTKMT2AL3MBTL1HTR1A | |
| SCHEMBL11117325 | 0.90 | KMT2A (0.57) | KMT2AHTR1ASMN1; SMN2SLC6A4 | |
| SCHEMBL11118598 | 0.88 | KMT2A (0.53) | GAAKMT2AL3MBTL1HTR1AMAPK1 | |
| SCHEMBL11010053 | 0.82 | DRD4 (0.64) | MAPTKMT2AHTR1AKDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL11015770 | 0.81 | LMNA (0.64) | MAPTKMT2AHTR1AKDM4EADRB2 | |
| SCHEMBL7079931 | 0.79 | KMT2A (0.56) | GAAMAPTKMT2AL3MBTL1HTR1A | |
| SCHEMBL10784748 | 0.79 | HTR1A (0.51) | MAPTKMT2AHTR1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL11013120 | 0.79 | KMT2A (0.60) | KMT2AHTR1AADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL11014416 | 0.79 | KMT2A (0.60) | MAPTKMT2AHTR1AKDM4EMAPK1 | |
| Hydrochloric Acid SCHEMBL11010332 | 0.79 | HTR1A (0.50) | GAAMAPTKMT2AHTR1AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112191-A1 | 4-(1H-indolyl-3-)-alpha-methyl piperidine-1-ethanol derivatives, their salts, process for their preparation, compositions containing them and their use as medicines | ROUSSEL-UCLAF (FR) | 1984-06-27 | — | — | EP | disclosed |