Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11103008 | 0.75 | TAAR1 (0.39) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11100934 | 0.72 | TAAR1 (0.37) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10968242 | 0.71 | SMN1; SMN2 (0.38) | PDE3BPDE3ATAAR1HTR1ACYP1A2 | |
| SCHEMBL10648317 | 0.70 | CYP1A2 (0.39) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL9522462 | 0.69 | TAAR1 (0.47) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10650151 | 0.69 | CYP1A2 (0.41) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10724402 | 0.69 | TAAR1 (0.35) | PDE3BPDE3ATAAR1HTR1APDE4A | |
| SCHEMBL10651361 | 0.68 | KMT2A (0.38) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10647923 | 0.68 | CYP1A2 (0.38) | PDE3BPDE3ACYP1A2KMT2AMEN1 | |
| SCHEMBL10645457 | 0.68 | CYP11B1 (0.56) | PDE3BPDE3ACYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |