Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10730668 | 0.80 | PDE3B (0.38) | SMN1; SMN2PDE3BPDE3ALMNAMAPT | |
| SCHEMBL10724402 | 0.78 | TAAR1 (0.35) | PDE3BPDE3ATAAR1PDE4APDE4B | |
| SCHEMBL10927112 | 0.76 | PDE3B (0.52) | SMN1; SMN2PDE3BPDE3ALMNAMAPT | |
| SCHEMBL10727054 | 0.76 | TAAR1 (0.36) | TAAR1HTR1A | |
| SCHEMBL10730636 | 0.74 | TAAR1 (0.35) | SMN1; SMN2PDE3BPDE3ATAAR1PDE4B | |
| SCHEMBL10724228 | 0.74 | CA12 (0.39) | SMN1; SMN2LMNAMAPTTAAR1CYP1A2 | |
| SCHEMBL10650242 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2PDE3BPDE3ALMNAMAPT | |
| SCHEMBL10648684 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE3BPDE3ALMNAMAPT | |
| SCHEMBL10650433 | 0.71 | HRH3 (0.46) | SMN1; SMN2PDE3BPDE3ALMNAMAPT | |
| SCHEMBL11114157 | 0.71 | PDE3B (0.47) | PDE3BPDE3ALMNATAAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071059-B1 | 6-(5-(OMEGA-(1-IMIDAZOLYL)-ALKYL)-THIEN-2-YL)-3-OXO-2,3,4,5-TETRAHYDROPYRIDAZINES AND THEIR ACID-ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1986-09-24 | — | — | EP | claimed |
| US-4504479-A | 6-{5-[ω-(1-Imidazolyl)-alkyl]-thien-2-yl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof and a process for the treatment of inflammatory atherosclerotic and thrombo-embolic, illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-12 | — | — | US | claimed |
| EP-0071059-A2 | 6-(5-(Omega-(1-imidazolyl)-alkyl)-thien-2-yl)-3-oxo-2,3,4,5-tetrahydropyridazines and their acid-addition salts, process for their preparation and pharmaceutical compounds containing them | A. Nattermann & Cie. GmbH (DE) | 1983-02-09 | — | — | EP | claimed |
| EP-0071059-B1 | 6-(5-(OMEGA-(1-IMIDAZOLYL)-ALKYL)-THIEN-2-YL)-3-OXO-2,3,4,5-TETRAHYDROPYRIDAZINES AND THEIR ACID-ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| US-4504479-A | 6-{5-[ω-(1-Imidazolyl)-alkyl]-thien-2-yl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof and a process for the treatment of inflammatory atherosclerotic and thrombo-embolic, illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-12 | — | — | US | disclosed |