Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646403 | 0.91 | CYP3A4 (0.43) | CYP3A4CYP2D6HTR2ASLC6A4 | |
| SCHEMBL10648690 | 0.81 | CYP11B1 (0.46) | SIGMAR1MEN1CYP3A4GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL10651008 | 0.81 | CYP11B1 (0.46) | MEN1CYP3A4GAACYP2D6MAPT | |
| SCHEMBL10648854 | 0.80 | CYP11B1 (0.47) | MEN1CYP3A4GAACYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL10646340 | 0.79 | CYP11B1 (0.46) | MEN1CYP3A4GAACYP2D6MAPT | |
| SCHEMBL10650408 | 0.76 | CYP11B1 (0.45) | MEN1CYP3A4GAACYP2D6MAPT | |
| SCHEMBL10646977 | 0.76 | CYP11B1 (0.45) | MEN1CYP3A4GAACYP2D6MAPT | |
| Hydrochloric Acid SCHEMBL10648154 | 0.75 | CYP11B1 (0.44) | MEN1CYP3A4GAACYP2D6MAPT | |
| SCHEMBL10648332 | 0.75 | ACHE (0.39) | SIGMAR1MEN1CYP3A4GAACYP2D6 | |
| SCHEMBL10646247 | 0.73 | CYP3A4 (0.45) | CYP3A4CYP2D6HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |