Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991213 | 0.86 | TRPA1 (0.52) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL28283404 | 0.85 | TRPA1 (0.47) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL873143 | 0.84 | TAAR1 (0.61) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL759880 | 0.84 | TAAR1 (0.61) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL9908239 | 0.84 | TAAR1 (0.61) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL11744344 | 0.83 | SLC6A2 (0.50) | TRPA1TAAR1KDM4ECYP2D6TSHR | |
| SCHEMBL13909501 | 0.83 | TRPA1 (0.52) | TRPA1TAAR1KDM4ECYP2D6ALDH1A1 | |
| SCHEMBL15481758 | 0.83 | TRPA1 (0.53) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL18901666 | 0.82 | LMNA (0.58) | TRPA1TAAR1KDM4EADRA2CCYP2D6 | |
| SCHEMBL17892871 | 0.82 | LMNA (0.58) | TRPA1TAAR1KDM4EADRA2CCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11618748-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2023-04-04 | — | — | US | disclosed |
| US-11236443-B2 | Fibers formed from a blend of a modified aliphatic-aromatic copolyester and theremoplastic starch | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210363141-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | ALCON INC. (CH) | 2021-11-25 | — | — | US | disclosed |
| EP-3828172-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| US-20210002792-A1 | Fibers Formed from a Blend of a Modified Aliphatic-Aromatic Copolyester and Theremoplastic Starch | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2021-01-07 | — | — | US | disclosed |
| EP-3354643-B1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS INC (US) | 2020-10-28 | — | — | EP | disclosed |
| EP-2044251-B1 | BIODEGRADABLE ALIPHATIC POLYESTER FOR USE IN NONWOVEN WEBS | NATUREWORKS LLC (US) | 2019-10-02 | — | — | EP | disclosed |
| US-10316029-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-10174017-B2 | Dual mechanism inhibitors for the treatment of disease | AERIE PHARMACEUTICALS, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| CN-105102420-B | Polyetheramines based on 1, 3-diols | 巴斯夫欧洲公司 | 2018-09-21 | — | — | CN | disclosed |
| WO-2009024836-A1 | MULTICOMPONENT BIODEGRADABLE FILAMENTS AND NONWOVEN WEBS FORMED THEREFROM | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2009-02-26 | — | — | WO | disclosed |
| WO-2008008068-A1 | BIODEGRADABLE ALIPHATIC-AROMATIC COPOLYESTER FOR USE IN NONWOVEN WEBS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008074-A1 | BIODEGRADABLE POLYACTIC ACID FOR USE IN NONWOVEN WEBS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008067-A1 | BIODEGRADABLE ALIPHATIC POLYESTER FOR USE IN NONWOVEN WEBS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| EP-1160245-B1 | PROCESS FOR PRODUCING CARBONYL COMPOUNDS BY DEHYDROGENATION OF ALCOHOLS | MITSUBISHI CHEM CORP (JP) | 2007-11-14 | — | — | EP | disclosed |
| US-6492532-B2 | Method for producing carbonyl compound by dehydrogenating alcohol | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-12-10 | — | — | US | disclosed |
| US-20020002289-A1 | Method for producing carbonyl compound by dehydrogenating alcohol | MITSUBISHI CHEMICAL CORPORATION (JP) | 2002-01-03 | — | — | US | disclosed |
| EP-1160245-A1 | PROCESS FOR PRODUCING CARBONYL COMPOUNDS BY DEHYDROGENATION OF ALCOHOLS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-12-05 | — | — | EP | disclosed |
| EP-0369249-A2 | Process for the preparation of cyclic carbonates | BAYER AG (DE) | 1990-05-23 | — | — | EP | disclosed |
| US-4623736-A | INTERMEDIATES FOR ANALGESICS | THE UPJOHN COMPANY (US) | 1986-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11618748-B2 | Dual mechanism inhibitors for the treatment of disease | RHOA, SLC6A2, ROCK2 | TRPA1 3206/4885TAAR1 456/4885KDM4E 2956/4885 |
| US-10316029-B2 | Dual mechanism inhibitors for the treatment of disease | RHOA, SLC6A2, ROCK2 | TRPA1 3206/4885TAAR1 456/4885KDM4E 2956/4885 |
| US-20210363141-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | RHOA, SLC6A2, ROCK2 | TRPA1 3206/4885TAAR1 456/4885KDM4E 2956/4885 |
| US-10174017-B2 | Dual mechanism inhibitors for the treatment of disease | RHOA, SLC6A2, ROCK2 | TRPA1 3206/4885TAAR1 456/4885KDM4E 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.