Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647854 | 0.89 | HSD17B10 (0.72) | HSD17B10ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1647420 | 0.85 | HSD17B10 (0.70) | HSD17B10ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23067450 | 0.85 | HSD17B10 (0.67) | HSD17B10ALDH1A1ALOX15NPC1RAB9A | |
| SCHEMBL2928667 | 0.82 | HSD17B10 (0.69) | HSD17B10ALDH1A1ALOX15SMN1; SMN2NPC1 | |
| SCHEMBL4473338 | 0.81 | HSD17B10 (0.61) | HSD17B10ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12381279 | 0.80 | L3MBTL3 (0.62) | HSD17B10ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL12381290 | 0.79 | L3MBTL3 (0.61) | HSD17B10ALDH1A1KDM4E | |
| SCHEMBL1647477 | 0.79 | HSD17B10 (0.60) | HSD17B10ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11091860 | 0.79 | NPC1 (0.63) | HSD17B10ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2932586 | 0.78 | HSD17B10 (0.58) | HSD17B10ALDH1A1SMN1; SMN2NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115413-A1 | +/- 2-(Phenethyl)-5-((3,4-methylenedioxy)-alpha-hydroxybenzyl)-pyrrolidines, pharmaceutical compositions containing them, processes for their production and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1984-08-08 | — | — | EP | disclosed |