Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930580 | 0.89 | HSD17B10 (0.60) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL11116524 | 0.82 | HSD17B10 (0.89) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8085160 | 0.82 | HPGD (0.62) | HSD17B10SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL27716110 | 0.79 | MRGPRX4 (0.54) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2932851 | 0.78 | MRGPRX4 (0.56) | NPC1RAB9ASMN1; SMN2MRGPRX4LMNA | |
| SCHEMBL2927457 | 0.77 | MRGPRX4 (0.68) | RAB9ASMN1; SMN2TP53MRGPRX4 | |
| SCHEMBL1647854 | 0.75 | HSD17B10 (0.72) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL14288610 | 0.74 | RAB9A (0.70) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL7336764 | 0.74 | ALDH1A1 (0.67) | TP53ALDH1A1HPGDPOLB | |
| SCHEMBL19549596 | 0.74 | SMN1; SMN2 (0.53) | HSD17B10SMN1; SMN2NPSR1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653134-B2 | Hydroxyphenol derivatives, processes for the preparation thereof, pharmaceutical compositions them, and therapeutic uses thereof | MERCK PATENT GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| EP-1836150-B1 | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2010-09-15 | — | — | EP | disclosed |
| US-20080161308-A1 | e.g. 4-[6-(2-cyclohexylethoxy)-3-oxoindan-5-yloxy]butanoic acid; peroxisome proliferator-activated receptor (PPAR) gamma agonist; antiinflammatory, antidiabetic agent; dyslipidaemia, atherosclerosis, insulin resistance | MERCK PATENT GMBH (DE) | 2008-07-03 | — | — | US | disclosed |
| CN-101098846-A | Hydroxyphenol derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic uses thereof | MERCK PATENT GMBH (DE) | 2008-01-02 | — | — | CN | disclosed |
| EP-1836150-A1 | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | Merck Patent GmbH (DE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006074798-A1 | HYDROXYPHENOL DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161308-A1 | e.g. 4-[6-(2-cyclohexylethoxy)-3-oxoindan-5-yloxy]butanoic acid; peroxisome proliferator-activated receptor (PPAR) gamma agonist; antiinflammatory, antidiabetic agent; dyslipidaemia, atherosclerosis, insulin resistance | PPARG, PPARA, PPARD | HSD17B10 380/4885NPC1 1307/4885RAB9A 2973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.