SCHEMBL11116844

SCHEMBL11116844

NC(=O)NS(=O)(=O)c1ccsc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.56
CYP3A4 P08684 2/20 0.56
KMT2A Q03164 2/20 0.56
TSHR P16473 1/20 0.56
LMNA P02545 1/20 0.54
NPSR1 Q6W5P4 1/20 0.53
KDM4E B2RXH2 1/20 0.51
EDNRA P25101 3/20 0.49
FABP4 P15090 11/20 0.47
HSD17B10 Q99714 1/20 0.46
FABP3 P05413 2/20 0.46
FABP2 P12104 2/20 0.46
FABP5 Q01469 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11117907 0.83 EDNRA (0.53) MEN1KMT2ATSHRLMNAKDM4E
SCHEMBL11532397 0.79 LMNA (0.62) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL5208861 0.77 LMNA (0.62) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL11724432 0.77 LMNA (0.63) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL12293612 0.75 MEN1 (0.76) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL11472500 0.74 LMNA (0.65) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL2531253 0.73 LMNA (0.68) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL9728565 0.73 LMNA (0.62) MEN1CYP3A4KMT2ATSHRLMNA
Hydrochloric Acid SCHEMBL28256990 0.73 LMNA (0.62) MEN1CYP3A4KMT2ATSHRLMNA
SCHEMBL10759398 0.72 EDNRA (0.48) MEN1CYP3A4KMT2ATSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0127469-A2 Antidotes for sulfonylurea herbicides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-05 EP claimed
EP-0127469-A2 Antidotes for sulfonylurea herbicides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-05 EP disclosed
EP-0030142-A2 Herbicidal ureas, preparation, compositions and use thereof E.I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-10 EP disclosed