Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11114119 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2TDP1LMNAKDM4ECYP1A2 | |
| SCHEMBL11113413 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL11190458 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL11251574 | 0.72 | GRIA1 (0.52) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL11097790 | 0.71 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL12969498 | 0.69 | GRIA1 (0.38) | TDP1KDM4ECYP1A2GRIA1GRIA2 | |
| SCHEMBL11398926 | 0.69 | LMNA (0.57) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL11300900 | 0.68 | LMNA (0.51) | SMN1; SMN2TDP1LMNAKDM4ECYP1A2 | |
| SCHEMBL10934487 | 0.68 | MET (0.42) | SMN1; SMN2LMNAKDM4ECYP1A2GRIA1 | |
| SCHEMBL15691459 | 0.68 | DUT (0.38) | TDP1LMNAPOLBMAPK1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049144-A1 | 5-Fluoro uracil derivatives | BEECHAM GROUP PLC (GB) | 1982-04-07 | — | — | EP | claimed |
| EP-0049144-B1 | 5-FLUORO URACIL DERIVATIVES | BEECHAM GROUP PLC (GB) | 1984-08-29 | — | — | EP | disclosed |
| EP-0049144-A1 | 5-Fluoro uracil derivatives | BEECHAM GROUP PLC (GB) | 1982-04-07 | — | — | EP | disclosed |